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KMID : 1141020210210010048
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Journal of Applied Oriental Medicine
2021 Volume.21 No. 1 p.48 ~ p.54
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Analysis of research on change in pharmacological properties of Rehmannia glutinosa (Gaertn.) DC. depending on processing
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Lee Ji-Hye
Moon Byeong-Cheol
Choi Go-Ya
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Abstract
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Processing is a traditional pharmaceutical technique in Korean medicine. Processing is mainly performed to enhance pharmacological effect of herbal medicine depending on specific clinical need. The root of Rehmannia glutinosa (Gaertn.) DC. (RR) is one of major herbal material in Korean medicine. Since nature of RR is altered by processing, the clinical use of RR varies based on processing method. Generally, fresh RR is used to treat blood-heat syndrome, while steamed RR is used to treat Yi-deficiency syndrome. This review summarized the up-to-date studies to investigate how processing affects pharmacological properties of RR. Using electronic database, a total of 13 studies were collected and included in this study. These studies exhibited pharmacological properties of RR including immunostimulatory, hematopoietic, blood-cooling, anti-oxidant, anti-tumor, anti-thrombosis and anti-ulcer effects. All of studies were conducted by using in vitro or in vivo bioassays. This study could help to establish the basis for future research on processing of RR. In order to provide comprehensive data, further study is needed which includes changes in chemical profiles and analysis of relation between chemical profiles changes and pharmacological properties.
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KEYWORD
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Rehmannia glutinosa, Rehmanniae Radix, processing, pharmacological effect
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